45.若病人的失眠屬於難維持型（difficulty maintaining sleep），下列何者是較佳的選擇？
(A)ramelteon
(B)eszopiclone
(C)zaleplon
(D)triazolam

難入睡用短效；難維持用中效

(B)eszopiclone 

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(1)BZD
短效：triazolam, midazolam

中效：estazolam, lorazepam, temazepam

長效：flunitrazepam, flurazepam, clonazepam, nitrazepam, fludiazepam, clobazam

(2)non BZD

短：Zaleplon, Zolpidem(10mg hs)

中：Zolpidem(延長釋放劑型，12mg hs), Zopiclone

(3)Melatonin agonists

Ramelteon(減少入睡所需時間)

(4)Orexin receptor antagonists (食慾素受體阻斷)

Suvorexant (增加睡意及入睡時間)