109年 - 109 國立中山大學_碩士暨碩士專班招生考試試題_生醫所碩士班：細胞暨分子生物學#119274

科目：研究所、轉學考(插大)◆細胞暨分子生物學 | 年份：109年 | 選擇題數：20 | 申論題數：8

試卷資訊

所屬科目：研究所、轉學考(插大)◆細胞暨分子生物學

選擇題 (20)

1. Which of the following is NOT a cytoskeleton protein? (A) Actin, (B) Microtubule, (C) Intermediate filament, (D) Syntaxin, (E) Spectrin
2. Which of the following is a coding RNA? (A) snRNA, (B) rRNA, (C) mRNA, (D) tRNA, (E) snoRNA
3. Lamin is a skeleton protein and found in (A) Plasma membrane, (B) Nucleus, (C) Golgi apparatus, (D) Mitochondrion, (E) Lysosome
複選題
4. Which of the following is the characteristic of lagging strand primers? (A) Composed of RNA, (B) Made by DNA polymerase, (C) Incorporated into the newly-synthesized strand, (D) Generated from 3' to 5',(E) All of them
複選題
5. Where dose protein glycosylation take place? (A) Plasma membrane, (B) Nucleus, (C) Golgi apparatus, (D) Mitochondrion, (E) Endoplasmic reticulum
6. During translation, the peptide bond formation requires (A) Ribosomal protein, (B) rRNA, (C) Charged tRNA, (D) GTP, (E) All of them
7. The carboxy-terminal domain (CTD) of RNA polymerase II involves (A) Promoter clearance, (B) Elongation, (C) Splicing, (D) Polyadenylation, (E) All of them.
8. Which of the following amino acid residue is NOT modified to regulate gene expression or signal transduction? (A) Alanine, (B) Lysine, (C) Serine, (D) Arginine, (E) Threonine
9. Eukaryotic primary transcripts are usually composed of (1) 5'-UTR, (2) Exon, (3) Intron, and (4) 3'- UTR, but their full length cDNAs only contain (A) 1+2+3, (B) 2, (C) 1+2+4, (D) 2+3, (E) 1+2+3+4
10. Which protein does NOT directly contact DNA? (A) Histone, (B) Repressor, (C) RNA polymerase, (D) Co-activator, (E) TATA-box binding protein
11. The enzyme responsible for joining two separate DNA strands is (A) Helicase, (B) DNA polymerase, (C) Topoisomerase, (D) Ligase, (E) Transposase.

12. The structure that storages in the cell is (A) Peroxisome, (B) Nucleus, (C) Golgi complex, (D) Mitochondrion, (E) Endoplasmic reticulum.
13. Which of the following chromosome region is transcriptionally active? (A) Barr body, (B) Heterochromatin, (C) Telomere, (D) Centromere, (E) None of them
14. The major activity of lysosome does NOT include (A) Breaking down biomolecules, (B) Fusing and digesting organelles, (C) Pumping in protons to keep its interior acidic, (D) Cooperating with proteasome, (E) Conducting autophagy.
15. Which of the following protein is responsible for vesicle trafficking (A) Importin, (B) Cohesin, (C) Kinesin, (D) Innexin, (E) Capping protein
16. Which of the following enzymes has proofreading activity? (A) Reverse transcriptase, (B) DNA polymerase II, (C) RNA polymerase, (D) Taq polymerase, (E) All of them
17. Endocytosis does NOT require (A) SNARE complex, (B) Clathrin, (C) Caveolin, (D) AP2 adaptor, (E) Dynamin
18. All of the following statements about nuclear pore complex (NPC) are true EXCEPT: (A) NPCs control the transport of molecules across the nuclear envelope, (B) No protein can freely pass through the NPC, (C) NPCs are made up of nucleoporins, (D) Importins transport cargo proteins with a nuclear localization signal (NLS) to the nucleus, (E) Ran is essential for the translocation of RNA and proteins through the nuclear pore.
19. All of the following enzymes can cleave the DNA strand and rejoin the breaks EXCEPT (A) Gyrase, (B) Endonuclease, (C) Integrase, (D) Transposase, (E) Recombinase.
20. Which of the following process is different in mitosis and meiosis? (A) Cell division, (B) DNA replication, (C) Chromosome condensation, (D) DNA recombination, (E) Chromatid alignment

申論題 (8)

(a) Cytokinesis
(b) Tight junction
(c) Induced pluripotent stem cells
(d) Okazaki fragments
(e) Chromatin remodeling
(f) Spliceosome
(2)請說明RNA interference的作用機轉及其應用？(10分)
(3)請從細胞構造與膜蛋白生合成兩方面來簡述prokaryotes與eukaryotes的差異。(10分)