試題詳解

24. T cell activation is a tightly regulated process. Which of the following mechanisms contribute to the downregulation or suppression of T cell signaling? (Select all that apply)
(A) CTLA-4 binding to B7 molecules on antigen-presenting cells
(B) PD-1 binding to PD-L1 or PD-L2 on antigen-presenting
(C) Recruitment of the Cbl family of ubiquitin ligases
(D) Production of immunosuppressive cytokines like IL-10 and TGF-B
(E) Increased expression of co-stimulatory molecules like CD28