1. When you decide to start a genomic study with the establishment of an expressed sequence tag or EST library, the first step you need to do is to (A) isolate total DNA from the target cells and then digest DNA with a mixture of restriction enzymes (B) isolate total RNA from the target cells and then make cDNAs via reverse transcription (C) extract cellular proteins and then digest them with selected proteinases (D) cultivate the target cells and then fix them with glutaldehyde/paraformaldehyde