1. Which of the following statement regarding opioids is wrong:
(A) Opioids inhibit voltage-dependent calcium channels.
(B) Opioids attenuate excitability of terminals or neurons.
(C) Opioid receptors are located postsynaptically on interneurons.
(D) Opioid cause antinociception by decreased activity in inhibitory descending controls.
(E) Important supraspinal sites opioid actions are the periaqueductal grey and the rostroventral medulla.

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