10. Sickle cell anemia is a molecular disease of hemoglobulin. The altered properties of hemoglobin S result from a single amino acid mutation. The following statement which is right? (A) a Leu instead of a Asp residue (B) a Ile instead of a Asn residue (C) a Val instead of a Glu residue (D) a Leu instead of a Gln residue (E) a Met instead of a Asn residue

10. Sickle cell anemia is a molecular disease of hemoglobulin. The altered properties of hemoglobin S result from a single amino acid mutation. The following statement which is right?
(A) a Leu instead of a Asp residue
(B) a Ile instead of a Asn residue
(C) a Val instead of a Glu residue
(D) a Leu instead of a Gln residue
(E) a Met instead of a Asn residue

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B1 · 2025/09/20

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3. When the divalent antibody was made monovalent by separating the antigen-binding domains (Fabs) from the constant domain (F), the Fab portion, but not the F. portion, bound the EGF receptor. Neither portion triggered cell proliferation. Which of the following conclusions is best supported by these results? (A) EGF binds a divalent antibody but not a monovalent antibody. (B) Signal transduction requires EGF or a monovalent antibody. (C) Binding of the Fab portion alone leads to internalization of the receptor. (D) Only a divalent antibody recognizes the binding site for EGF. (E) Dimerization of EGF receptors by a divalent antibody leads to signal transduction.

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