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試卷名稱：114年 - [無官方正解]114 國立清華大學_碩士班入學考試試題_生命科學暨醫學院甲組(生物與醫學科學組)：分子生物學#132699
年份：114年
科目：研究所、轉學考(插大)◆分子生物學
15. Which of the following statements is INCORRECT about the canonical
microRNA (miRNA) biogenesis pathway in mammals?
(A) Pri-miRNAs are typically transcribed by RNA polymerase II and contain a 5'
cap and polyA. tail.
(B) The Microprocessor complex, composed of Drosha and DGCR8, cleaves primiRNAs in the nucleus to generate pre-miRNA hairpins.
(C) Exportin-5, in a Ran-GTP-dependent manner, exports pre-miRNAs from the
nucleus into the cytoplasm.
(D) Dicer cleaves the pre-miRNA in the cytoplasm, producing a short duplex
(~22 nucleotides), which then undergoes strand selection.
(E) The mature miRNA is incorporated into the RNA-induced silencing complex
(RISC) through the Drosha-DGCR8 complex.
