16. Which of the following description about the catalytic reaction is correct? (E: enzyme； S: substrate) (A) Uncompetitive inhibitors bind only to the ES complexes at a place distinct from the active site. (B) Reversible inhibition must be the type of competitive inhibition. (C) Competitive inhibitors compete with the enzymes by binding to the active sites on the substrates. (D) The activity of enzyme is quite stable and may not be affected by environmental pH. (E) None of the above.