16.8歲女童因鼻塞，其母親至藥局選購含pseudoephedrine 6 mg/mL和 triprolidine 0.25 mg/mL的糖漿劑。下列 用藥指導何者錯誤？
(A)糖漿劑可長期服用，停用後不會造成反彈性鼻充血（rebound congestion）
(B)pseudoephedrine為短效性藥品，可每6小時服用一次
(C)服用此藥品，須留意可能有口乾、嗜睡等不適
(D)當症狀緩解後，可以立即停藥

口服和鼻內去充血劑皆不可長期使用，作鼻塞症狀緩解用

鼻內去充血劑可能有藥物性鼻炎的副作用（使用10天以上產生反彈現象）

(B)

pseudoephedrine 一般情況下半衰期約4-6小時

Ref. 台灣過敏性鼻炎治療指引

1) Triprolidine is a member of the propylamine (alkylamine) chemical class of H-1 antagonist antihistamines. As such, it is considered to be relatively less sedating than traditional antihistamines of the ethanolamine, phenothiazine, and ethylenediamine classes of antihistamines. Triprolidine has a shorter half-life and duration of action than most of the other alkylamine antihistamines [36].

2) Like all H-1 antagonist antihistamines, the mechanism of action of triprolidine is believed to involve competitive blockade of H1-receptor sites resulting in the inability of histamine to combine with its receptor sites and exert its usual effects on target cells. Antihistamines do not interrupt any effects of histamine which have already occurred. Therefore, these agents are used more successfully in the prevention rather than the treatment of histamine-induced reactions [36].