23. Which of the following mutations is correctly defined?

(A) Silent: change of a single base in the non-coding intron region of a gene

(B) Missense: substitution of a single base results in a premature stop codon

(C) Permissive: results in a protein that has greater thermodynamic stability

(D) Frameshift: deletion of a single base results in a single amino acid change

(E) Nonsense: substitution of a single base results in a complete change of amino acid sequence