阿摩線上測驗
28. 有關 113 年 3 月寶林食物中毒案，下列何者錯誤？
(A) 被認為與細菌產生的毒素汙染食物有關
(B) 該毒素抑制呼吸作用
(C) 使腺嘌呤核苷三磷酸未能離開粒線體
(D) 由於毒素專門攻擊呼吸系統，導致患者窒息
答案：登入後查看
統計： A(7), B(9), C(34), D(159), E(0) #3420690
統計： A(7), B(9), C(34), D(159), E(0) #3420690
詳解 (共 3 筆)
後中123
#6365934
42. 近來引起食安問題的邦克列酸(Bongkrekic Acid)，是因其和粒線體膜上何種蛋白結合，造成細胞缺乏能量？
(A) ATP 合成酶(ATP Synthase)
(B) 細胞色素 C(Cytochrome C)
(C) 腺嘌呤核苷酸轉運蛋白(Adenine nucleotide translocase)
(D) 細胞色素 C 還原酶(Cytochrome C reductase)
答案：C
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7. 邦克列酸 (Bongkrekic acid)為一種致病毒素，存在於受致病型唐菖蒲伯克氏(Burkholderia gladioli)汙染後的穀物、椰子或濕麵條等食物中。以下針對此種毒素之描述何者正確？
(A) 毒性弱，需要大量攝入才會引發疾病
(B) 它會誘發細胞內無法控制的大量產生 ATP
(C) 它干擾內線粒體內膜上的 ADP/ATP 轉換
(D) 其不需要滲透至粒線體即可產生毒性
(E) 高溫可以破壞其毒性
答案：C
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[補充—其他抑制呼吸作用的抑制劑]
◎ Complex I (NADH ubiquinone oxidoreductase) — 魚藤酮 rotenone
70. Which of the following compounds can prevent electron transfer from the Fe-S center to ubiquinone in oxidative phosphorylation process?
(A) Rotenone
(B) Cyanide
(C) 2,4-Dintrophenol
(D) Oligomycin
(E) Valinomycin
答案：A
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24. Which protein complex in the mitochondrial electron transport chain has the largest molecular weight and is also inhibited by rotenone?
(A) Complex I (NADH: ubiquinone oxidoreductase)
(B) Complex II (Succinate dehydrogenase)
(C) Complex III (Cytochrome bc₁ complex)
(D) Complex IV (Cytochrome oxidase)
(E) Complex V (ATP synthase)
答案：A
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◎ Complex II (Succinate dehydrogenase)—Malonate
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◎ Complex III (Cytochrome bc₁ complex) — antimycin A
47. What is the primary inhibition mechanism of antimycin on oxidative phosphorylation, and what are the consequences?
(A) Inhibition of complex Ⅰ, leading to decreased electron transport and reduced ATP production.
(B) Inhibition of complex Ⅱ causing disruption in the citric acid cycle and impaired generation of reducing equivalents.
(C) Inhibition of complexⅢ, resulting in the blockade of electron transfer and a decrease in the proton motive force.
(D) Inhibition of ATP synthase, preventing the conversion of the proton motive force into ATP synthesis.
(E) Inhibition of complex TV, leading to the disruption of the final step in the electron transport chain and a decrease in oxygen consumption.
答案：C
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◎ Complex IV (Cyt C oxidase) — 氰化物 Cyanide、CO、H2S
16. What complex can be inhibited by hydrogen cyanide (HCN)?
(A) Complex I
(B) Complex II
(C) Complex III
(D) Complex VI
(E) Complex V
答案：D (IV誤植成VI，送分)
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14. 有關氰化物(cyanide)與二硝基苯酚(dinitrophenol)影響細胞呼吸作用的敘述，下列何者最為恰當？
(A) 氰化物會抑制 ATP 合成酶(ATP synthase)；二硝基苯酚則是減少粒線體內膜對 H+ 的滲透力 (permeability)
(B) 氰化物可阻礙電子在電子載體(electron carriers)間傳遞；二硝基苯酚則是減少 H+ 穿過粒線體內膜
(C) 氰化物減少 H+ 由粒線體內膜流出，抑制 H+ 濃度梯度的形成；二硝基苯酚則是阻礙電子在 電子載體(electron carriers)間的傳遞
(D) 氰化物可視為電子傳遞阻礙劑(electron transport blocker)；二硝基苯酚則是讓H+ 不經由ATP 合成酶穿過粒線體內膜
答案：D
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◎ Complex V (Fo-F1 ATP Synthase) — 寡黴素 oligomycin
20. Which of the following best describes the mechanism of action of oligomycin?
(A) inhibition of Complex I
(B) blocking of ATP synthase proton channel
(C) uncoupling of oxidative phosphorylation
(D) blocking of cytochrome c function
(E) inhibition of Complex III
答案：B
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