3. Which of the following contradicts the one-gene, one-enzyme hypothesis?
(A) Alkaptonuria results when individuals lack a single enzyme involved in the catalysis of homogentisic
acid.
(B) Sickle-cell anemia results in defective hemoglobin.
(C) A mutation in a single gene can result in a defective protein.
(D) A single antibody gene can code for different related proteins, depending on the alternative splicing.
(E) No case contradicts the one-gene, one-enzyme hypothesis.
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