36. Which of the following statement regarding glycolysis is true?
 1. Hexokinase undergo a distinct conformational change when it binds glucose.
 2. The phosphorylation of glucose to glucose 6-phosphate is an exergonic reaction that is coupled to the endergonic hydrolysis of ATP.
 3. The binding of glucose to hexokinase is an example of induced-fit binding of a substrate to the active site of an enzyme.
 4. The phosphorylation of fructose 6-phosphate to fructose-1,6-bisphosphate is the committed step in glycolysis because it is the most strongly exergonic step in the pathway.
(A) 1 and 2 are correct.
(B) 3 and 4 are correct.
(C) 1 and 3 are cotrect.
(D) 2 and 4 are correct.
(E) All are correct.