38.下列何者最不可能降低體內 vitamin D 含量？
(A)cholestyramine
(B)isoniazid
(C)orlistat
(D)phenytoin

來自：Dilantin Kapseals 仿單

phenytoin會使25(OH)D體內濃度降低，但是1,25(OH)₂D體內濃度增加，phenytoin造成之骨骼病變和25(OH)D較有關

The results suggest that the bone disease resulting from phenytoin therapy may be associated with a deficiency of 25-hydroxycholecalciferol and not of 1 alpha, 25-dihydroxycholecalciferol, and that reduced gastrointestinal absorption of calcium or changes in parathyroid function may not be necessary for the development of bone disease.


https://pubmed.ncbi.nlm.nih.gov/220903/


chrome-extension://gphandlahdpffmccakmbngmbjnjiiahp/http://www.tsim.org.tw/journal/jour25-4/03.PDF