39. Which one of the following intervention provides the worst therapeutic effect of pain relief for lumbar spinal radicular pain?
(A) transforaminal epidural steroids injection
(B) radiofrequency denervation
(C) spinal cord stimulation
(D) lumbar sympathetic block
(E) caudal steroids injection

35. During peripheral sensitization of nociceptors, which of the coupling is wrong? (A) prostaglandin E2 (PGE2) --- EP receptor (B) bradykinin --- B2 receptor (C) heat --- TRPV1 receptor (D) ATP --- P2Y receptor (E) all of the above are right

36. Arrange the pain intensity of the following conditions from the strongest to the least according to long form McGill Pain Questionnaire. 1 Labor pain, 2 Amputation of digit, 3 Male low abdominal surgery, 4 Fracture: (A) 1＞2＞3＞4 (B) 2＞1＞4＞3 (C) 2＞1＞3＞4 (D) 1＞2＞4＞3 (E) None of above is right

37. Regarding the actions of spinal and supraspinal analgesia for opioids, which of the following statement is most likely: (A) Opioid receptors are mostly located at a predominantly 70% postsynaptic location on the central terminals of only small diameter nociceptive primary afferents. (B) The contribution of kappa, delta and mu receptors to the total opiate binding throughout the spinal cord is estimated to be delta ＞ mu ＞kappa.(C) Opioids inhibit OFF cells via GABA neurons and activate ON cells in the rostromedial medulla (RVM) leading to changes in spinal descending controls. (D) Nitric oxide (NO) is required for the 5-HT-mediated inhibition of PAG output and reversal of antinociception. (E) Fibers descending from the PAG to the dorsal horn of the spinal cord are mostly enkephalinergic, glycinergic and GABAergic.

38. 當病人一再來門診或急診要求注射成癮性止痛藥時，下列哪些現象暗示病患可能有「成癮」 現象？ (A) 病人抱怨最近的處方的止痛時間不夠久，藥效變差 (B) 病患抱怨最近疼痛加重厲害，發作頻繁，他把三天的藥一天吃完 (C) 病人自述出現嗜睡、噁心、性欲降低、便秘，但是疼痛都沒有減輕 (D) 病人自述沒吃止痛藥會睡不著，希望睡前加重劑量輔助睡眠 (E) 病人最近反覆敘述藥物遺失，而且發生很多次

40. Which of the following statement concerning hypnotic analgesia is least likely: (A) Hypnosis has been highly associated with theta activity (4~8 Hz) using EEG methods. (B) Hypnotic analgesia can be understood as the result of a placebo manipulation, and it is not more than just relaxation. (C) Increases in hypnotic relaxation are associated with increases in regional cerebral blood flowin the occipital cortex. (D) Deep relaxation, dissociated imagery and focused analgesia produced significant reductions on all pain-related measures. (E) Descending projections from amygdale, PAG and locus coeruleus contribute to modulate nociceptive processes in the brain stem and the spinal cord.

41. A parturient of heroin abuse history ask for painless labor, which one is improper? (A) Meperidine (B) Continuous epidural analgesia (C) Nitrous oxide (D) Butorphanol (E) Intrathecal morphine

42. Which of the following is the unacceptable statement about peripheral nerve block? (A) Occipital nerve block is indicated for occipital and posterior auricular neuralgia. (B) Lateral cutaneous nerve of the thigh: local anaesthetic block of this nerve is indicated for diagnosis and treatment of meralgia paresthetica. (C) Sacral plexus block, transforaminal through the sacral foramina, may be indicated for temporary relief of sciatic pain. (D) Suprascapular nerve block is indicated for postsurgical pain relief, for assessment of shoulder pain and to facilitate physical therapy of the shoulder joint in painful shoulder stiffness and pain secondary to CRPS. (E) For classical trigeminal neuralgia, blocks of the Gasserian ganglion with glycerol or radiofrequency are now the commonly used alternatives when microvascular decompression is not available or cannot be used.

43. Indications for lumbar epidural steroid injections include all of the following, EXCEPT? (A) Radicular pain with corresponding sensory change (B) Radiculopathy due to herniated disc with failed conservative treatment (C) Acute herpes zoster in the lumbar dermatomes (D) Post laminectomy failed back syndrome without radiculopathy

44. Which of the following is the acceptable statement about pathogenesis of FMS? (A) There is evidence to suggest that FMS is a disorder of abnormal processing of sensory information within the central nervous system. (B) Several neurochemical mediators of pain, substance P, nerve growth factor, dynorphin A, glutamate, nitric oxide, serotonin and noradrenaline are viewed as pronociceptive because they carry or amplify afferent signals, leading to the brain perception of increased pain. (C) The elevation of cerebrospinal fluid substance P in FMS is due to lowered activity of cerebrospinal fluid substance P esterase because the rate of cleavage of libeled substance P by FMS cerebrospinal fluid was lower than normal. (D) In different subtypes of FMS, it is believed that nerve growth factor may be responsible for the elevated cerebrospinal fluid substance P through its effects on central sensitization and neuroplasticity. (E) A specific Gi-protein–coupled receptor in peripheral blood leukocytes was found to be dysfunctional in patients with FMS. This resulted in lower baseline, also depressed intracellular levels of cyclic AMP and proposed as a diagnostic test for FMS.

45. A 52-year-old man complains of a sudden onset of severe stabbing pain in the left jaw and cheek that subsides in less than a minute. He is pain-free during the intervals between attacks. Activities such as combing his hair and shaving can cause the onset of this facial pain. He is otherwise healthy. The most likely diagnosis is? (A) Atypical facial pain (B) Vascular facial pain (C) Postherpetic neuralgia (D) Trigeminal neuralgia