阿摩線上測驗
41.下列關於thrombomodulin的敘述，何者正確？
(A)參與抑制Factor VIII
(B)參與抑制Tissue factor
(C)參與活化Factor V
(D)參與抑制Plasminogen activator inhibitor-1
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統計： A(963), B(180), C(228), D(461), E(0) #1381570
統計： A(963), B(180), C(228), D(461), E(0) #1381570
詳解 (共 6 筆)
etrnya
#1464333
Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin.
Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin.
Protein C is a major component in anticoagulation in the human body. It acts as a serine protease zymogen: APC proteolyses peptide bonds in activated Factor V and Factor VIII (Factor Va and Factor VIIIa), and one of the amino acids in the bond is serine.[13]:2381 These proteins that APC inactivates, Factor Va and Factor VIIIa, are highly procoagulant cofactors in the generation of thrombin, which is a crucial element in blood clotting; together they are part of the prothrombinase complex
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