43. Which of the following statement concerning “joint pain” is least likely? (A) In a normal joint, only intense pressure on the joint and movements exceeding the working range elicit pain. (B) Under pathological conditions such as joint inflammation, hypersensitivity of the nociceptive system occurs frequently and leads to pain on palpation. (C) Mechanical sensitization of joint nociceptors is generated by numerous inflammatory mediators, including prostaglandins and cytokines. (D) Spinal sensitization involves excitatory amino acids, neuropeptides, and spinal prostaglandins. (E) Better understanding of pain mechanisms can't improve pain therapy.