44.Factor V Leiden造成的主要影響為何？
(A)加速prothrombinase complex生成
(B)穩定fibrin clot
(C)Activated protein C resistance檢測呈現陽性
(D)促進anticoagulation

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統計： A(189), B(213), C(1280), D(220), E(0) #1150978

詳解 (共 4 筆)

#1597480
Factor V Lieden為Factor V突變導致對活化的protein C的作用產生抗性
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#4877442
APTT上升   factor5不被AP...
(共 37 字，隱藏中）
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#1464813

Activated protein C (with protein S as a cofactor) degrades Factor Va and Factor VIIIa. Activated protein C resistance is the inability of protein C to cleave Factor Va and/or Factor VIIIa, which allows for longer duration of thrombin generation and may lead to a hypercoagulable state. This may be hereditary or acquired.[3] The best known and most common hereditary form is Factor V Leiden. Acquired forms occur in the presence of elevated Factor VIII concentrations.

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#7262863
這題考的是遺傳性血栓風險因子中最重要的...
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