46 Amiodarone 為抗心律不整的藥品，有關其敘述，何者錯誤？
(A) 口服的起始作用(Onset)約為6 小時
(B) 半衰期約為15-100 天
(C) 可以延長心房與心室纖維的不反應期
(D) 可能造成視力方面的副作用

答案：登入後查看
統計： A(74), B(8), C(14), D(39), E(0) #443711

詳解 (共 3 筆)

#2926735

Onset：2 to 3 days but more commonly 1 to 3 wk

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#2926731

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#864848
Oral amiodarone is markedly lipophilic, resulting in a very large volume of distribution (average about 66 L/kg) and a prolonged time to reach stable plasma levels [1]. It is incompletely absorbed (approximately 30 to 70 percent) after oral administration and is taken up very extensively by tissue, with marked interindividual variation [2]. Estimates of the elimination half-life of amiodarone vary, depending on how the half-life has been measured and the route of amiodarone administration. The relatively short half-life for disappearance of amiodarone from plasma after a single-dose or short-term intravenous administration is likely a measure of drug redistribution from vascular space into tissue and not true body elimination. After long-term oral therapy, amiodarone has a true elimination half-life between 60 and 142 days [2,3]. Slow and wide distribution to tissue (fat, muscle, highly perfused organs) results in a requirement of long loading periods in an effort to accelerate the onset of drug activity. However, even with loading, arrhythmia recurrence during the first months of therapy does not necessarily predict long-term efficacy.
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