49. As we know, bone scan is the most common diagnostic tool for bone metastasis. Which limitation is incorrect? (A) Bone scan is characterized by high sensitivity and high specificity (B) Any positive findings should be corresponded to painful sites with further evaluation of CT or plain radiographs (C) Bone scan doesn't evaluate the structural integrity (D) Most common pattern of metastasis in bone scan is "hot spot" with radioisotope accumulation for new bone reaction (E) Some cancers may not show "hot spot" pattern, such as melanoma and multiple myeloma