阿摩線上測驗
50.抗生素藥敏試驗採用 Susceptible Dose Dependent（SDD）判讀標準，下列何者非其原因？
(A)新興抗生素研發成果有限
(B)使用更高劑量可能具治療效果
(C)可促使臨床醫師有效利用現有藥物
(D)降低使用頻率亦可能具有治療效果
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統計： A(345), B(767), C(144), D(963), E(0) #3064175
統計： A(345), B(767), C(144), D(963), E(0) #3064175
詳解 (共 3 筆)
燊泱叡張
#7283167
M100-S25版本-->CLSI M100-S28版本，同時更新針對腸內菌(Enterobacteriaceae)的Cefepime抗生素藥敏試驗判讀的欄位結果中Intermediate (I)改為Susceptible Dose Dependent (SDD)
腸內菌(Enterobacteriaceae)於Cefepime的判讀標準異動如下，報告格式由I (intermediate)異動為SDD (susceptible-dose dependent)，判讀為SDD之結果將以「D」格式核發
<2019年的資料>
來源資料:http://www.erhlin.cch.org.tw/LabSearch/news_detail.aspx?oid=119&no=6
CLSI
susceptible-dose dependent (SDD) – a category defined by a breakpoint that implies that susceptibility of an isolate depends on the dosing regimen that is used in the patient. To achieve levels that are likely to be clinically effective against isolates for which the susceptibility testing results (either minimal inhibitory concentrations
[MICs] or zone diameters) are in the SDD category, it is necessary to use a dosing regimen (ie, higher doses, more frequent doses, or both) that results in higher drug exposure than that achieved with the dose that was used to establish the susceptible breakpoint
腸內菌(Enterobacteriaceae)於Cefepime的判讀標準異動如下，報告格式由I (intermediate)異動為SDD (susceptible-dose dependent)，判讀為SDD之結果將以「D」格式核發
<2019年的資料>
來源資料:http://www.erhlin.cch.org.tw/LabSearch/news_detail.aspx?oid=119&no=6
CLSI
susceptible-dose dependent (SDD) – a category defined by a breakpoint that implies that susceptibility of an isolate depends on the dosing regimen that is used in the patient. To achieve levels that are likely to be clinically effective against isolates for which the susceptibility testing results (either minimal inhibitory concentrations
[MICs] or zone diameters) are in the SDD category, it is necessary to use a dosing regimen (ie, higher doses, more frequent doses, or both) that results in higher drug exposure than that achieved with the dose that was used to establish the susceptible breakpoint
來源資料:https://clsi.org/media/3226/m100-s29_definitions_correction_notice_2.pdf
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