59.下列對抗病毒藥物acyclovir的敘述，何者錯誤？
(A)可用來治療單純疱疹病毒
(B)其藥物需要經由病毒蛋白酶（protease）切割後才能發揮作用
(C)主要是抑制病毒DNA聚合酶（DNA polymerase）作用
(D)病毒的thymidine kinase基因突變可能會導致病毒對acyclovir產生抗藥性

Aciclovir is converted by viral thymidine kinase to aciclovir monophosphate, which is then converted by host cell kinases to aciclovir triphosphate (ACV-TP).^[23] ACV-TP, in turn, competitively inhibits and inactivates HSV-specified DNA polymerases preventing further viral DNA synthesis without affecting the normal cellular processes.^[23][33][34]

Resistance

Resistance to aciclovir is rare in people with healthy immune systems, but is more common (up to 10%) in people with immunodeficiencies on chronic antiviral prophylaxis (transplant recipients, people with acquired immunodeficiency syndrome due to HIV infection). Mechanisms of resistance in HSV include deficient viral thymidine kinase; and mutations to viral thymidine kinase or DNA polymerase, altering substrate sensitivity.