59.Olanzapine口溶錠劑型不適用於罹患phenylketonuria者，因其製劑中內含下列何種成份？
(A)Aspartame
(B)Benzalkonium chloride
(C)Diethylhexylphthalate
(D)Tartrazine

Olanzapine口溶錠劑型含有人工甘味劑aspartame，Aspartam在體內代謝形成苯丙氨酸(phenylalanine) 甲醇 及aspartic acid，故不適用於罹患phenylketonuria者

phenylketonuria苯酮尿症（ＰＫＵ）Phenylketonuria is an autosomal recessive metabolic genetic disorder characterized by homozygous or compound heterozygous mutations in the gene for the hepatic enzyme phenylalanine hydroxylase, rendering it nonfunctional. This enzyme is necessary to metabolize the amino acid phenylalanine to the amino acid tyrosine. When PAH activity is reduced, phenylalanine accumulates and is converted into phenylpyruvate, which can be detected in the urine.