6. Which of the following mammalian cell DNA polymerases is not correctly matched with its function?
(A) DNA Pol E-DNA repair
(B) DNA Pol 8-ligation of DNA strands
(C) DNA Pol y-elongation of both strands
(D) DNA Pol B-DNA repair
(E) DNA Pol a-priming DNA synthesis

2. Which of the following is the best definition of translation? (A) a process by which pre-mRNA is transformed into mature mRNA (B) the process by which pre-mRNA is translated by ribozymes to produce proteins (C) a process by which a gene is converted into mRNA (D) a process by which a gene is converted into a protein (E) the process by which ribosomes read the genetic message to produce a protein

3. In the Meselson and Stahl experiment, what percentage of the DNA is labeled with light nitrogen after three generations of replication? (A) 25% (B) 50% (C) 75% (E) None of the above. (D) 100%

4. If Hershey and Chase found in progeny phages rather than , their experiment would have demonstrated that (A) proteins contain phosphorus. (C) phage DNA enters the host cell. (E) None of the above. (B) DNA contains sulfur. (D) phage protein enters the host cell.

5. In which of the following organisms is trans-splicing of mRNA known to occur? (A) trypanosomes (C) bacteria (E) plants (B) yeast (D) mammals

7. The probe used in chromatin immunoprecipitation is _____ to select the target chromatin fragments. (A) DNA (B) RNA (C) protein (D) antibody (E) gRNA

8. The polyA. tail of eukaryotic mRNA is approximately _____ nucleotides in length (A) 1000 (B) 250 (C) 100 (D) 25 (E) 5

9. Please put the following steps of Cap synthesis in the correct order. (1) N of the capping guanine is methylated. (2) The terminal phosphate is removed from the pre-mRNA. (3) A capping GMP is added to the pre-mRNA. (4) The 2'-O-methyl group of the penultimate nucleotide is methylated. (A) 1, 2, 3, 4(B) 1, 4, 3, 2 (C) 2, 4, 1, 3(D) 2, 3, 1, 4 (E) 4, 3, 2, 1

10. Which of the following is not needed for mammalian cell polyadenylation of pre-mRNA? (A) RNA polymerase (B) RNA polymerase II (C) PAP (D) CPSF (E) PABII

11. In human global genome nucleotide excision repair (GG-NER), which products are correct for the "incision" function? (A) XPF and XPG (B) XPB and XPD (C) ХРА and XPC (D) XPA and XPB

複選題12. Choose a right statement on Telomerase or Telomere (A) Telomerase was first observed in Tetrahymena micronuclei extracts. (B) Telomerase is a unique enzyme in that it is composed of only RNA. (C) Without telomeres, linear eukaryotic chromosomes would get shorter and shorter with each round of DNA replication (D) All organisms must protect their telomeres from nucleases and double strand break repair enzymes.