60.當須併用moxifloxacin與MgO時,通常會建議moxifloxacin在給與MgO之前,至少須間隔若干小時服用?
(A)0.5
(B)1
(C)2
(D)4
統計: A(11), B(199), C(1037), D(1597), E(0) #537451
詳解 (共 10 筆)
(A)0.5
(B)1
(C)2
(D)4
(A)1
(B)2
(C)3
(D)4
FQ裡moxi需要間隔最久,
cipro 2 hr before or 6 hr after
levo 2 hr before or 2 hr after
moxi 4 hr before or 8 hr after
Magnesium Salts: May decrease the serum concentration of Quinolones. Management: Administer oral quinolones several hours before (4 h for moxi/pe/spar-, 2 h for others) or after (8 h for moxi-, 6 h for cipro/dela-, 4 h for lome/pe-, 3 h for gemi-, and 2 h for levo-, nor-, or ofloxacin or nalidixic acid) oral magnesium salts.
UpToDate Moxifloxacin (systemic)
Oral fluoroquinolones should be taken 2 hours before or 4 hours after any products containing these cations. (Basic and clinical pharmacology 13th ed. p.812)
怎麼看起來好像是如果先服用FQ的話隔兩小時;如果先服用多價離子的話隔4小時?
“What is the most important information I should know about AVELOX?"
Certain medicines may keep AVELOX from working correctly. Take AVELOX either 4 hours before or 8 hours after taking these products:
● An antacid, multivitamin, or other product that has magnesium, aluminum, iron, or zinc
● Sucralfate (Carafate®)
● Didanosine oral suspension or solution
ref: moxifloxacin FDA仿單
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf