67 有關王老先生血脂異常之處置,下列口服處方中,何者是首選?
(A) Cholestyramine 4 g tid
(B) Lovastatin 80 mg hs
(C) Niacin ER 1 g hs
(D) Pravastatin 20 mg qd

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統計: A(11), B(72), C(12), D(111), E(0) #416421

詳解 (共 5 筆)

#2306267
Pravastatin不經過CYP代謝,...
(共 40 字,隱藏中)
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#1075128
口服Pravastatin,主要透腸肝循環排出,腎臟排出極少,適用於腎功能不佳之病患。
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#2898962

Pravastatin is the statin of choice in patients on cyclosporine.

uptodate還特地把上述列成單獨一點!!

The risk is substantially increased for most statins extensively metabolized by cytochrome P450 3A4 (lovastatin, simvastatin and to a lesser extent atorvastatin) with concurrent therapy with drugs that interfere with CYP3A4 

Pravastatin, fluvastatin, rosuvastatin, and pitavastatin are preferred when concurrent therapy with a strong inhibitor of CYP3A4 cannot be avoided.

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#2254826
Statins不是不可併Cyclospo...
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#4108858
因pravastatin不被CYP450...
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