69 下列何者與 mercaptopurine 有嚴重的交互作用？
(A) Mycophenolate mofetil
(B) Mycophenolate sodium
(C) Allopurinol
(D) Cyclosporine

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統計： A(20), B(6), C(417), D(11), E(0) #417463

詳解 (共 1 筆)

#984853
Severe bone marrow suppression and other toxicity have been associated with concomitant use of allopurinol and mercaptopurine (6-MP) or azathioprine. 
 
Allopurinol inhibition of 6-MP first-pass metabolism via hepatic or intestinal xanthine oxidase, the enzyme that catalyzes the inactivation of 6-MP.
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