阿摩線上測驗
7.下列何種藥物不屬於alkylating agents？
(A)Cyclophosphamide
(B)Carmustine
(C)Thiotepa
(D)Fluorouracil
統計： A(390), B(462), C(798), D(6809), E(0) #1738088
詳解 (共 10 筆)
D.Fluorouracil 為抗代謝藥物-Pyrimidine antagonists
補充最佳解答案
1.cyclophosphamide的解毒劑=>Mensa，因為acrolin會有膀胱毒性
2-1.葉酸抑制劑、嘧啶抑制劑都是抑制thymidylate synthase
2-2.葉酸抑制劑
2-3.嘌呤抑制劑
3.trimethoprim,pyrimethamine也是抑制DHFR
4.氣體滅菌法，常用氣體為環氧乙烯
複習-無細胞週期專一性之抗癌藥
|
分類 |
機轉 |
抗癌活性來源 |
副作用 |
藥物 |
|
Nitrogen muatard |
l interstrand crosslinking l 烷化DNA-guanine N-7 |
aziridinium ion |
易誘發白血病 |
Cyclophosphamide、Ifosfamide、Mechlorethamine、Mephalan、Chlorambucil、Bendamustine |
|
Ethylene-imines |
l interstrand crosslinking |
|
|
Thiotepa. Triethylene. Melamine. Diaziquone. Altretamine |
|
Alkyl sulfonate |
l interstrand crosslinking l 進行剝硫反應 烷化DNA N7 |
|
|
Busulfan
|
|
有機鉑複合物 |
l intrastrand crosslinking l 烷化 DNA guanine N7 |
|
|
Cisplatin (不可冰) carboplatin oxaliplatin (PO) |
|
Nitrourea |
l 無 cross linking l 烷化DNA guanine O6 |
Carbonium ion |
|
Carmustine. Lomustine. Streptozotocin(Streptozocin) |
|
DNA Methylator |
methyl radical |
|
procarbazine |
|
|
methyl carbocation (diazonium ion) |
|
Dacarbazine Temozolomide(PO) |
