72 下列 lithium 與各藥物產生交互作用之敘述中，何項錯誤？
(A)與 losartan 併用產生腎毒性
(B)與 methyldopa 併用產生神經毒性
(C)與 fluoxetine 併用可能增加 lithium 之濃度
(D)與 theophylline 併用增加 lithium 於腎臟之排除

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統計： A(71), B(32), C(52), D(95), E(0) #417998

詳解 (共 7 筆)

#2319554

覺得沒答案

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#1035819
Coadministration with ACE inhibitors may increase serum lithium concentrations and the risk for lithium toxicity. Several mechanisms may be involved, one of which is rduced renal lithium clearance due to natriuresis secondary to the inhibition of aldosterone and angiotensin II by ACE inhibitors. The combination may also cause renal dysfunction secondary to volume depletion during chronic therapy, which can further impair lithium clearance.
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#4108878
 losartan 主要由肝代謝
(共 19 字，隱藏中）
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#895330
(A)與 captopril 併用產生腎毒性 
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#2319553

(B)increased CNS response to lithium

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#3762984

Losartan也會造成濃度上升

Concurrent use of LITHIUM and ANGIOTENSIN RECEPTOR BLOCKERS may result in increased risk of lithium toxicity.

Coadministration of lithium and this drug may increase the risk of lithium toxicity. If concomitant use is required, reduce the initial lithium dosage, titrate slowly, and frequently monitor serum lithium concentrations and for signs of lithium toxicity (Prod Info LITHOBID® oral extended release tablets, 2016). 

ref:Micromedex


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#6544595
增加Lithium濃度 降低Lit...

(共 210 字，隱藏中）
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