75.有關基因多型性（genetic polymorphism）對藥動學影響之敘述，下列何者正確？
(A)CYP2C9之基因多型性會顯著影響phenytoin之代謝
(B)CYP2C19之基因多型性會顯著影響propranolol之代謝
(C)CYP2D6之基因多型性會顯著影響omeprazole之藥動學性質
(D)CYP1A2之基因多型性會顯著影響codeine之代謝

Enzymes

Substretes

Inhibitors

Inducers

CYP1A2

Amitriptyline

Clomipramine

Clozapine

Fluvoxamine

Imipramine

Theophylline

R-Warfarin

Caffeine

Amiodarone

Cimetidine

Ciprofloxacin

Fluvoxamine

Omeprazole

Broccoli

Brussels sprouts

Cigarette

Smoking

CYP2B6

Bupropion

Midazolam

Tamoxifen

Verapamil

Ketoconazole

Dexamethasone

Phenobarbital

Rifampin

Valproic acid

CYP2C9

Celecoxib

Diazepam

Diclofenac

Fluoxetine

Fluvastatin

Glibenclamide

Glimepiride

Glipizide

Ibuprofen

Irbesartan

Losartan

Meloxicam

Naproxen

Phenytoin

S-Warfarin

Amiodarone

Fluconazole

Isoniazid

Rifampin

Secobarbital

CYP2C19

Amitriptyline

Citalopram

Clopidogrel

Diazepam

Lansoprazole

Omeprazole

Pantoprazole

Proguanil

Propanolol

R-Warfarin

Chloramphenicol

Cimetidine

Ketoconazole

Lansoprazole

Omeprazole

Oxcarbazepine

Pantoprazole

Carbamazepine

Rifampin

CYP2D6

Amitriptyline

Carvedilol

Chlorphenamine

Chlorpromazine

Clomipramine

Codeine

Dextromethorphan

Donepezil

Duloxetine

Fluoxetine

Haloperidol

Imipramine

Metoclopramide

Metoprolol

Ondansetron

Oxycodone

Paroxetine

Propranolol

Tamoxifen

Timolol

Tramadol

Venlafaxine

Amiodarone

Bupropion

Celecoxib

Cimetidine

Citalopram

Clomipramine

Duloxetine

Escitalopram

Fluoxetine

Levomepromazine

Paroxetine

Quinidine

Sertraline

Terbinafine

Rifampin

CYP2E1

Acetaminophen

Chlorzoxazone

Enflurane

Ethanol

Halothane

Sevoflurane

Disulfiram

Ethanol

Isoniazid

CYP3A4

Amiodarone

Amlodipine

Antipyrine

Aripiprazole

Atorvastatin

Buspirone

Ciclosporin

Clarithromycin

Dexamethasone

Diazepam

Diltiazem

Domperidone

Erythromycin

Estradiol

Felodipine

Fentanyl

Finasteride

Hydrocortisone

Indinavir

Lercanidipine

Lopinavir

Methadone

Nelfinavir

Nifedipine

Progesterone

Ritonavir

Saquinavir

Sildenafil

Simvastatin

Tacrolimus

Testosterone

Verapamil

Vindesine

R-Warfarin

Cimetidine

Clarithromycin

Diltiazem

Erythromycin

Fluconazole

Indinavir

Itraconazole

Ketoconazole

Nelfinavir

Ritonavir

Saquinavir

Verapamil

Grapefruit Juice

Carbamazepine

Efavirenz

Glucocorticoid

Nevirapine

Oxcarbazepine

Phenobarbital

Phenytoin

Pioglitazone

Rifampin

St John’s Wort

P-gp

Cyclosporin

Etoposide

Fexofenadine

Paclitaxel

Terfenadine

Vinblastine

Amiodarone

Azithromycin

Carvedilol

Clarithromycin

Digoxin

Erythromycin

Itraconazole

Ketoconazole

Propafenone

Quinidine

Ritonavir

Spironolactone

Verapamil

Carbamazepine

Dexamethasone

Nifedipine

Phenobarbital

Phenytoin

Rifampin

St.John's Wort