76.下列建議何者最不適當?
(A)levofloxacin 750 mg PO QD AC
(B)micafungin 50 mg IV QD
(C)valacyclovir 500 mg PO Q12H
(D)valganciclovir 900 mg PO Q12H
答案:登入後查看
統計: A(296), B(869), C(401), D(872), E(0) #3133843
統計: A(296), B(869), C(401), D(872), E(0) #3133843
詳解 (共 7 筆)
#6012514
關於(D)選項
原文書中有提到
In the CMV-seronegative HCT recipient, primary CMV infection or disease can be prevented by selecting a CMV-seronegative donor and using only blood products from CMV-seronegative donors. No anti CMV prophylaxis is required in these recipients. In patients who are CMV-seropositive or who have received a CMV-seropositive graft, antiviral drugs are essential to minimize morbidity associated with CMV reactivation or secondary infection.
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基本上就是說在移植時只要選用非CMV帶原者的移植物就不需要擔心會有CMV感染的風險,當然就也不用給予預防用藥
需注意的是CMV和VZV一樣是會終身潛伏於人體內的,所以曾受過CMV感染的患者或是接受CMV帶原者的移植物才需要預防給藥
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通常建議是使用IV Ganciclovir 5mg/kg Q12H 誘導1~2週,接下來使用5mg/kg QD的維持劑量持續到檢測不到CMV抗原後2~3週或是移植後100天
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也可以使用口服的Valganciclovir 900mg Q12H誘導1~2週,接下來使用900mg QD的維持劑量持續1~2週或是檢測不到抗原為止 (BY.UpToDate)
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ref:Applied 10th、UpToDate
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#6488190
垃圾題目
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#6010923
Valganciclovir常用治療劑量是900 mg QD
選項(D) Valganciclovir 900 mg PO Q12H 太高了
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#6016331
Valtrex is used to treat infections with shingles (herpes zoster), genital herpes (herpes simplex genitalis), and cold sores (herpes labialis)
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Valcyte is used to prevent disease caused by a virus called cytomegalovirus (CMV) in people who have received organ transplants and cancer chemotherapy treatment and to treat CMV retinitis in people with AIDS.
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