申論題

9. It has been well-studied that several hormones can promote prostate cancer cell growth: (I) Testosterone can enter the cells and then be converted to DHT, a specific ligand for androgen receptor (AR); (2) Epidermal Growth Factor (EGF) will signal through EGF receptor (EGFR) to promote cancer cell proliferation. Please answer the following questions based on what you have learned about signaling transduction. (8%)

2) Upon Testosterone binding to AR, what will happen next? (more than one correct answer) (3%) A) AR Dimerization B) AR degradation C) AR binding to DNA D) AR autophosphorylation of several tyrosine residues E) AR conformation change Tnstosterone JAK / STAT3 MEK / MAPK PIDK I AKT