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研究所、轉學考(插大)◆生化學
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112年 - 國立臺灣大學_碩士班招生考試_生物化學暨分子生物學研究所:生化學#113391
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題組內容
8. Decide whether the following statements are
True
or
False
, and then explain why. (6%)
5) Loss of the 3' to 5' exonuclease activity of DNA polymerase in E. coli should slow the rate of DNA synthesis but not affect its fidelity.
其他申論題
1 ) A telomere allows a chromosome to be replicated precisely so that no nucleotides are lost from the end of the chromosome, thereby solving the end-replication problem.
#484613
2 ) Nuclease-hypersensitive sites in chromatin are located in the linker DNA between nucleosomes.
#484614
3) If a DNA-binding protein forms a symmetric dimer, it is likely that the recognition site in the DNA is symmetric as well.
#484615
4) In general, the DNA replicating enzyme in E. coli is DNA polymerase I.
#484616
6) Pyrimidine dimmers are usually formed between two thymines in different strands.
#484618
9. Abnormalities in the catalytic activities of key enzymes are commonly linked to diseases. Please describe (at least) three possible causes that may lead to abnormal enzyme activities (6%).
#484619
1) serine protease (2%)
#484620
2) allosteric regulation (3%)
#484621
3) prosthetic group (2%)
#484622
4) competitive inhibitor (3%)
#484623
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