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46. Which of the following is NOT a methodological limitation of the study? (A) Heterogeneous patient sample (B) Variability of treatment regimens (C) Bias due to the treatment for each group was blinded (D) Long-term health economic effects

47. What was one of the impacts of the combination therapy with SAT and SLT? (A) Reduced direct and indirect non-medical costs (B) Reduced self-paid expenses and treatment time (C) Reduced use of standard treatment interventions (D) Reduced use of non-standard treatment interventions and medications

48. What information was true in Liu et al.’s design of research? (A) Different instruments were used to collect data such as questionnaires. (B) A total of 203 participants with Broca’s aphasia were equally allotted. (C) Both groups applied the SAT to determine the medical effects. (D) The data collection lasted for one month approximately.

48.若卵細胞以 EDTA 處理,則會造成下列何種現象? (A)頂體反應(acrosomal reaction)將被阻斷 (B)精卵核融合(fusion of sperm and egg nuclei)將被阻斷 (C)快速多精阻斷作用(fast block to polyspermy)不會發生 (D)受精膜(fertilization envelope)無法形成

49.阿茲海默症的神經退化過程,最主要涉及下列何種變化? (A)細胞外液離子濃度改變 (B)軸突髓鞘改變 (C)突觸的分子與結構改變 (D)軸突離子通道結構改變

50.在開發針對自體免疫疾病(如類風濕性關節炎)的調節性 T 細胞(Treg)相關療法時,下列何種策略 最符合目前的醫學研究方向? (A)使用單株抗體阻斷 Foxp3 蛋白,以活化患者的免疫系統 (B)透過體外擴增患者自身的 Treg 細胞,並確保其 Foxp3 表達穩定後再回輸患者體內 (C)給予高劑量的 IL-2 以刺激效應 T 細胞(Teff)的增生,進而壓制 Foxp3 的活性 (D)誘發 Treg 細胞轉化為 Th17 細胞,以增強局部的發炎反應來對抗病毒