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108年 - 108 學士後西醫 - 普通生物及生化概論#78641

科目：學士後西醫-普通生物及生化概論 | 年份：108年 | 選擇題數：45 | 申論題數：0

試卷資訊

所屬科目：學士後西醫-普通生物及生化概論

選擇題 (45)

16. An enzyme with a high turnover number has_______. (A) a low Km(B) a high kcat(C) a high Vmax (D) a high kcat/Km (E) a high Km
17. Which of the following descriptions for myoglobin is correct? (A) Myoglobin contains four subunits. (B) The binding of O2 with myoglobin shows cooperative kinetic. (C) O2 binds with Fe3+ of heme group in myoglobin. (D) 2,3-BPG does not affect the binding of O2 with myoglobin. (E) Myoglobin and hemoglobin are not evolutionarily related.
18. Which of the following parts of the IgG molecule are not involved in binding to an antigen? (A) Heavy chain(B) Light chain(C) Fab(D) Fc(E)Variable domain
19. Aspirin is well-known as an inhibitor of_______.(A) lipoxygenase (B) hormone sensitive lipase (C) cyclooxygenase (D) fatty acid synthase (E) acetyl-CoA carboxylase
20. Which is not derived from arachidonic acid? (A) lipoxin (B) prostaglandin (C) thromboxane (D) leukotriene (E) prednisone

21. In fatty acid synthesis, acetyl group is shuttled out of mitochondria as: (A) pyruvate (B) oxaloacetate (C) α-ketoglutarate (D) glutamine (E) citrate

22. Which of the metabolites in the urea cycle is linked to the citric acid cycle? (A) Citrulline(B) Argininosuccinate (C) Arginine(D) Ornithine
23. Which of the following amino acids is the crucial precursor for the biosynthesis of melatonin? (A) Phenylalanine(B) Methionine(C) Lysine(D) Tryptophan
24. Which is not an electron acceptor in the mitochondrial respiratory chain? (A) FMN(B) FAD(C) Fe3+(D) Cu2+ (E) Coenzyme A
25. Which is the active sugar in glycogen synthesis in animal? (A) CDP-glucose (B) GDP-glucose (C) UDP-glucose (D) Glucose 6-phosphate (E) Glucose 1-phosphate
26. Which of the following compounds is not a product of the enzymatic steps in the citric acid cycle? (A) Acetyl-CoA (B) -ketoglutarate (C) Succinate (D) Fumarate (E) Malate
27. Gout is caused by aberrant degradation of purine, leading to accumulation of uric acid. Allopurinol inhibits_______, leading to reduce the production of uric acid. (A) purine nucleoside phosphorylase (B) xanthine oxidase (C) nucleotidase (D) urease (E) hypoxanthine-guanine phosphoribosyltransferasse
28. Which of the following enzymes cannot catalyze the formation of a phosphodiester bond? (A) RNA polymerase (B) DNA polymerase (C) Ligase (D) Endonuclease (E) Reverse transcriptase
複選題
29. Histones are found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes. They are usually rich in _______, and they interact with DNA via _______. (A) lysine and arginine; ionic bonds (B) glutamic acid and aspartic acid; hydrogen bonds (C) alanine and glycine; ionic bonds (D) lysine and arginine; hydrogen bonds (E) glutamic acid and aspartic acid; ionic bonds

30. The binding of _______ with lac repressor can activate the transcription of lac operon. (A) arabinose (B) isopropyl β-thiogalactoside (C) tryptophan (D) β-galactosidase (E) mannose

61. A mixture of four amino acids is separated by using a cation exchanger with an elution gradient of increasing NaCl solution. What is the correct elution sequence? (A) Asp, Lys, Arg, Ser(B) Asp, Ser, Lys, Arg(C) Asp, Arg, Ser, Lys (D) Ser, Asp, Arg, Lys(E) Lys, Arg, Ser, Asp
62. For an α-has the sequence : +H3N-Asp-Trp-Gln-Leu-His-Val-Phe-Ala-Lys-Val-Glu-COO-, the carbonyl oxygen (in the peptide bond) of the histidine residue is hydrogen bonded to the amide nitrogen of _______. (A) Trp(B) Lys(C) Val(D) Gln(E) Leu
63. The carbohydrate moiety is always attached to glycoproteins through _______. (A) aspartate, glutamate or tyrosine(B) tryptophan, glutamine or alanine (C) cysteine, phenylalanine or histidine(D) asparagine, serine or threonine (E) valine, leucine or isoleucine

64. Which of the backbone repeated units of polysaccharides is not correct? (A) Amylose: (α1-4) Glc (B) Dextran: (α1-6) Glc (C) Glycogen: (α1-4) Glc (D) Cellulose: (β1-4) Glc (E) Chitin: (β1-4) Glc

65. Taking one mole of glucose through glycolysis and the citric acid cycle generates: (A) 6 CO2, 8 NADH/H+, 1 FADH2 and 1 ATP (B) 6 CO2, 8 NADH/H+, 1 FADH2 and 2 ATP (C) 6 CO2, 8 NADH/H+, 2 FADH2 and 4 ATP (D) 6 CO2, 10 NADH/H+, 2 FADH2 and 2 ATP (E) 6 CO2, 10 NADH/H+, 2 FADH2 and 4 ATP
66. Which of the following is a hetero-polysaccharide? (A) Cellulose (B) Chitin (C) Glycogen (D) Hyaluronate (E) Starch
67. Glycoaminoglycans consist of a linear chain of repeating disaccharides. Which of the following polysaccharide is not glycoaminoglycans? (A) Chondroitin sulfate(B) Keratan sulfate(C) Dermatan sulfate (D) Heparin(E) Sialic acid
68. Gluconeogenesis synthesizes glucose, while glycolysis catabolizes glucose. It is evident that gluconeogenesis and glycolysis must be controlled in reciprocal fashion. Which of the following enzymes for glycolysis are not used in the gluconeogenic pathway?①Hexokinase②Phosphofructokinase③Phosphoglycerate kinase ④Triosephosphate isomerase⑤Pyruvate kinase (A)①②③(B)①②④(C)①②⑤(D)②③⑤(E)③④⑤
69. The potent allosteric activator for phosphofructokinase-1 in glycolysis is _______.(A) fructose 1,6-bisphosphate (B) citrate (C) ATP (D) fructose 2,6-bisphosphate (E) acetyl-CoA
70. Which of the following compounds can prevent electron transfer from the Fe-S center to ubiquinone in oxidative phosphorylation process? (A) Rotenone(B) Cyanide(C) 2,4-Dintrophenol (D) Oligomycin(E) Valinomycin 
71. Which of the following fatty acids cannot be synthesized by human?(A) Linoleate [18:2(Δ9,12)] (B) Stearate (18:0) (C) Oleate [18:1(Δ9 )] (D) Palmitoleate [16:1(Δ9 )] (E) Arachidonate [20:4(Δ5,8,11,14)]
複選題

72. Ketone bodies are overproduced in diabetes and during starvation. Which of the following metabolites is not an intermediate from two molecules of acetyl-CoA to acetone? (A) Acetoacetyl-CoA (B) β-hydroxy-β-methylglutaryl-CoA (C) Acetoacetate (D) β-hydroxybutyrate (E) CoA-SH

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73. Which is not involved in fatty acid oxidation? (A) Starts from carboxylate end (B) Acyl-CoA dehydrogenase (C) Acyl-CoA hydratase (D) β-hydroxyacyl-CoA dehydrogenase (E) Acyl-CoA acetyltransferase

74. Which is the potent inhibitor of carnitine acyltransferase I? (A) Carnitine (B) Acetyl-CoA (C) Malonyl-CoA (D) Succinyl-CoA (E) Fumarate
75. Flippases are enzymes that flip _______. (A) phospholipids across to the other side of a membrane (B) cholesterol from one organelle to another (C) protons across to the other side of a membrane (D) D-glucose to L-glucose (E) L-form amino acids to D-form amino acids
 76. Degradation of amino acids can produce the precursors that are used to synthesize glucose or convert to ketone bodies. Which of the following amino acids can convert into precursors for the synthesis of glucose? 1. Leucine2.Lysine3. Cysteine4. Asparagine5. Methionine (A)123 (B) 124(C)234(D)245 (E) 345
77. A deficiency of branched chain α-keto acid dehydrogenease complex causes the defect in metabolism of amino acids. The accumulation of α-keto acid in urine leads to maple syrup urine disease. Which of the following amino acids are metabolized by α-keto acid dehydrogenease complex?            1.Methionine2.Leucine3.Isoleucine4.Valine5.Alanine (A)125(B)135(C)234(D)245(E)345
78. Defect in metabolism of phenylalanine causes phenylketounia and alkaptonuria. Which of the following statements are correct? ① A person with phenylketonuria will convert phenylalanine to phenylpyruvate. ② A person suffering from phenylketonuria on consumption food containing high phenylalanine may lead to the accumulation of tyrosine. ③ A person with phenylketonuria is advised not to consume aspartame.④ Alkaptonuria is due to defect in phenylalanine hydroxylase. ⑤ A person suffering from phenylketonuria on consumption food containing high phenylalanine may lead to the accumulation of acetoacetyl-CoA. (A)①② (B)①③ (C)①④ (D)②③ (E)②⑤
79. The de novo purine nucleotide synthesis relies upon the conversion of _______ to _______as a primary source of one carbon unit. (A) alanine; pyruvate (B) phenylalanine; tyrosine (C) serine; glycine (D) glutamate; -ketoglutarate (E) aspartate; oxaloacetate
80. Which of the following statements for thermal denatuation of DNA are false?1. The absorption of ultraviolet at 260 nm increases.2.The DNA helical structure unwinds. 3. The covalent N-glycosidic bond between the base and the deoxyribose breaks. 4.The melting temperature of DNA with 60% A+T content is lower than that with 20% G+C content. 5.The double-helical DNA becomes single-stranded DNA at melting temperature. (A)135(B)134(C)145(D)234(E)345
81. Which of the following enzymes does not require a template? (A) RNA polymerase II(B) DNA polymerase (C) Polyadenylate polymerase(D) Telomerase (E) Reverse transcriptase
82. Which is not a true statement about reverse transcriptase? (A) The direction of polynucleotide synthesis is 5' → 3'. (B) It has 3' → 5' exonuclease activity. (C) It synthesizes DNA complementary to an RNA template. (D) It synthesizes DNA complementary to a DNA template. (E) It degrades the RNA strand of the RNA-DNA hybrid.
83. Many proteins are involved in DNA replication of E. coli. Which of the following pairs of protein and function are correct? ①DNA gyrase, unwinding DNA ②DnaA, helicase ③DNA polymerase I, excises RNA primer and fills in with DNA④DNA polymerase II holoenzyme, 5' → 3' exonuclease⑤DNA polymerase III holoenzyme, elongation (DNA synthesis) (A)②③⑤(B)②③④(C)①③④(D)①③⑤(E)①①⑤
84. Which DNA repair system is likely to be used in repairing DNA with an uracil residue? (A) Base-excision repair (B) Mismatch repair (C) Direct repair (D) Nucleotide-excision repair (E) Recombinational DNA repair
85. Aptamers are _______. (A) double-stranded RNA products of nuclease action on hairpin RNAs (B) repeat sequence elements at the ends of transposons (C) small RNA molecules selected for tight binding to specific molecular targets (D) the RNA primers required for retroviral replication (E) the short tandem repeat units found in telomeres
86. Which of the following modification elucidates the inhibitory effect of diphtheria toxin on the function of eukaryotic translation factor eEF2? (A) Phosphorylation (B) Dephosphorylation (C) ADP-ribosylation (D) Prenylation(E) S-Nitrosylation
87. Elongation factor Tu (EF-Tu): (A) binds GTP promoting translocation of ribosomes along mRNA (B) displaces GDP from the elongation complex (C) binds aminoacyl-tRNA in the presence of GTP (D) binds initiator tRNA and GTP (E) binds to 30S subunit and drives mRNA binding
88. Selenocysteine (Sec) and pyrrolysine (Pyl) are recognized as 21st and 22nd amino acids, respectively. tRNASec and tRNAPyl have anticodon pairing with _______ and _______, respectively. (A) UAA, CUG(B) UGA, UAG(C) UAA, UAG(D) UAG, UGA(E) UAG, UAA
89. Which step about regulation of gene expression by insulin is not correct? (A) Insulin receptor binds insulin and undergoes autophosphorylation. (B) Insulin receptor binds IRS-1 on its Tyr residues. SH3 domain of Grb2 binds to phosphorylated Tyr of IRS-1. (C) Sos binds to Grb2, then to Ras, causing GDP release and GTP binding to Ras. (D) Activated Ras binds and activates Raf-1. (E) Raf-1 phosphorylates MEK. MEK phosphorylates MAPK, activating it.

90Which description about β-adrenergic pathway (a G-protein coupling receptor; GPCR) is not correct? (A) The receptor is a 7-transmembrane protein. (B) Epinephrine binds to a GPCR. (C) The occupied receptor could cause the replacement of the GDP bound to GS (stimulatory G protein) by GTP, activating GS. (D) GSβ moves to adenylyl cyclase and activates it to synthesize cAMP. (E) cAMP activates PKA to trigger cellular response.

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