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110年 - 110長庚大學_碩士班招生考試_生物醫學研究所︰藥理學#101173

科目：研究所、轉學考(插大)◆藥理學 | 年份：110年 | 選擇題數：33 | 申論題數：10

試卷資訊

所屬科目：研究所、轉學考(插大)◆藥理學

選擇題 (33)

1. In a system with a large percentage of spare receptors, which of the following statements is true? (A) EC50 ＞ Kd (B) EC50 ＜ Kd (C) EC50 = Kd (D) EC50 =1.4 Kd/CL
2. Which of the following statements about half-life is true? (A) Increases as bioavailability increases (B) Decreases as volume of distribution increases (C) Decreases as clearance increases (D) Decreases as elimination rate constant decreases
3. Drug A is a weak organic base with a pKa of 7.0. What percentage of a given dose will be in the lipid-soluble form at an urine pH of 6.0? (A) About 1% (B) About 10% (C) About 50% (D)About 90%
4. Which of the following is correct regarding responses mediated by adrenergic receptors? (A) Stimulation of al receptors increases blood pressure (B) Stimulation of 81 receptors reduces lipolysis (C) Stimulation of sympathetic presynaptic 42 receptors increases norepinephrine release (D) Stimulation of B2 receptors increases heart rate
5. An asthma patient was given a nonselective B agonist to relieve bronchoconstriction. Which of the following adverse effects would you expect to sce in this patient? (A) Bradycardia (B) Tachycardia (C) Hypotension (D) Worsening bronchoconstriction
6. Which of the following is correct regarding the autonomic nervous system? (A) Afferent neurons carry signals from the CNS to the effector organs (B) The neurotransmitter at the parasympathetic ganglion is norepinephrine (C) Sympathetic neurons release acetylcholine in the effiector organs (D) The neurotransmitter at the sympathetic ganglion is acetylcholine
19. A patient of BPAD has taken Jithium for 10 years； which biological index do you think he/she should be regularly checked? (A) Blood pressure (B) Cognitive test (C) Liver and respiratory function (D) Renal and thyroid function
20. What is the antidote for acute morphine over-dosage ? (A) Methadone (B) Pentazocine (C) Naloxone (D) Haloperidol
21. What is the major target of SSRI, fluoxetine ? (A) Dopamine D2 receptor (B) Adenosine Al receptor (C) Serotonin transporter (D) Vesicular monoamine transporter (VMAT)
22. Major molecular target of typical anti-psychotics ? (A) Glutamate NMDA receptor (B) Dopamine D2 receptor (C) Muscarinic acetylcholine receptor (D) Dopamine transporter
23. Cellular mechanism of carbi-dopa in treatment of Parkinson's disease ? (A) Enhance L-dopa absorption in GI tract (B) Increase the dopamine binding to dopamine D1 receptor (C) Reduce glutamate inhibition on central dopamine activity (D) Suppress peripheral dopa decarboxylase activity
24. Which of the following disease or disorder could NOT be treated by benzodiazepam ? (A) Epilepsy (B) Anxiety (C) Alcohol withdrawal syndrome (D) Depression
25.Which of the following cause could induce the epilepsy? (A) Reduced central dopamine activity (B) Increased central glutamate activity (C) Imbalanced activity of prefrontal GABA and norepinephrine (D) Enhanced GABA uptake in the striatum
26. Which one of the following drug class could NOT be used as a component in 'balanced anesthesia' ? (A) Neuromuscular blocker (B) Opioid analgesia (C) Antiemetics (D) Anti-depressant
27. Why epinephrine was frequently used in combination with local anesthesia during surgery? (A) Restricts the local blood circulation (B) Reduces the drug metabolism (C) Prevents the drug super-sensitivity (D) Reduces the cardiovascular side effect
28. How alpha-blockers may act as an antihypertensive agent considering BP = CO x SVR ? BP: blood pressure； CO: cardiac output； SVR: systemic vascular resistance (A) decrease intravascular volume (B) decrease cardiac contractility (C) decrease arterial resistance (D) decrease heart rate
29. Which of the following drugs are used in treatment of patients with Covid-19 to improve pulmonary function? (A) nitroprusside (B) captopril (C) alteplase (D) heparin
30. It has been demonstrated that thrombin binds to its receptor and induces a transient increase in the intracellular calcium level of vascular smooth muscle cells. After the intracellular calcium recovers to the basal level, the cells are no longer responsive to the 2nd challenges of thrombin. Which one of the following terms is the best description of this phenomenon? (A) tolerance (B) specificity (C) tachyphylaxis (D) withdrawal response
31. What is the action mechanism of beta blockers for prophylaxis of angina pectoris? (A) reduction of end-diastolic ventricular volume (B) blockade of exercise-induced tachycardia (C) shortened ventricular ejection time (D) increase in double product
32. What is the major action mechanism of beta blockers in treatment of chronic heart failure? (A) reduced myocardial work load (B) improved cardiac contractility (C) increased afterload (D) reduced preload
33. Drugs for treatment of asthma often induce hypokalemia, such as theophylline. Which one of the following is more appropriate in treatment of such patient with chronic hypertension? (A) labetalol (B) eplerenone (C) furosemide (D) chlorothiazide
34. Acetaminophen overdose can be lethal because of: (A) liver failure (B) renal failure (C) cardiac infarction (D) gastric ulcer-induced bleeding
35. Which of the following situation is the most likely to be the consequence of activation of TP receptor? (A) vasodilation in response to ischemia (B) thromboembolism in ischemic stroke (C) peptic ulcer after prolonged treatment of aspirin (D) constriction of bronchial smooth muscle in asthma
36. Atorvastatin reduces plasma cholesterol by: (A) attenuating liver triglycerol synthesis (B) interfering with bile acid reabsorption (C) inhibiting intestinal cholesterol absorption (D) inhibiting hepatic cholesterol biosynthesis
37. Toxicities of overdose of isotretinon does NOT include: (A) photoaging (B) sever sunburn when expose to sun light (C) teratogenic (D) photophobia
38. Calcipotriene is (which of the following descriptions is not correct?) (A) a topical vitamin A analog (B) has effects of a retinoid (C) activates RXR-alpha (D) modulate epidermal differentiation and inflammation E. treat psoriatic plaques
39. Antibiotics-induced diarrhea often is due to the activation of which of following receptors for an enhanced bowel movement (A) 5-HT4 receptor (B) Motilin receptor (C) Dopamine subtype 2 receptor (D) GABA receptor
40. Which of the following conditions or factors does NOT inhibit type I 5'-Deiodinase? (A) Ipodate (B) propanolol and esmolol (C) amiodarone (D) Selenium
41. Which of the following drugs is NOT an insulin secretagogue? (A) Glymepride ( a sulfonylurea) (B) Repaglinide (a Meglitinide) (C) Exenatide (a GLP-1 agonist) (D) Metformin (a Biguanide)
42. Which of the following insulin preparations needs to be sorted in low pH 4 solution to ensure its bioavailability of Insulin? (A) glargine (B) lispro (C) aspart (D) detemir
43. Which of the following anabolic androgen derivative(s) provide(s) the least risk for developing prostate cancer due to its modifying the testosterone structure to 19-NOR which increases its resistance to 5a-reductase? (A) methyltesterone and fluoxymesterone (B) 7a-methyl-19-nortesterone and tetradydrogestrione (C) Oxandrolone and Stanozolol (D) Danazol
44. Which of the following drugs produces Wolft-Chaikoff effect to treat which type of thyroid diseases? (A) Iodide and Lithium salt, hypothyroidism (B) Lugol's solution, hyperthyroidism (C) lodine containing diet, hypothyrodism, (D) Phenytoin, hyperthyroidism
45. Which of the following descriptions for licorice-induced hypertension is correct? (A) Glyeyrhizic acid inhibits 11B-hydroxysteroid dehydrogenase 1 and thus increase concentration of cortisol (B) Glycyhizic acid inhibits 11B-hydroxysteroid dehydrogenase 2 to increase cortisone concentration (C) Glycyrhizic acid increases concentration of cortisone to bind the aldosterone receptor (D) Glycyrhizic acid increases the concentration of cortisol to bind the mineral corticoid receptor

申論題 (10)

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