110年 - 110 國立臺灣大學_碩士班招生考試_部分系所:藥理學#102017

選擇題 (50)

1. Which of the following descriptions about ion channels is incorrect? (A) Sodium channel can let sodium ion pass. (B) Ion channel uses ATP to pump jons from one side to the other sidc of the channel. (C) Membrane potential can be a mechanism to control the open or close state of an ion channcl. (D) Ligand-gated ion channel needs a receptor binding site to control its open or close state.

2. Which of the following descriptions about benzodiazepinc is incorrect? (A) It is commonly used as hypnotics(安眠藥) (B) It acts on GABA receptor. (C) It enhances the GABA receptor function. (D) It binds to the GABA binding site.

3. Which of the following descriptions about sodium channel blockers is incorrect? (A) Lidocaine, a local anesthetics, can block sodium channel. (B)Tetrodotoxin(河豚毒素)is a pore blocker of sodium channel. (C) Phenytoin, an anti-epileptic drug, is a pore blocker of sodium channel. (D) Carbamazepinc, an anti-cpileptic drug, is a usc-dependent blocker of sodium channel.

4. Which of the following descriptions about receptor binding drugs is incorrect? (A) a-Bungarotoxin, a kind of snake poison, is an antagonist of GABA receptor. (B) Caffeine is an antagonist of adenosine receptor. (C) Ketamine is a NMDA neurotransmitter blocker. (D) Ondansetron, an antiemetics (止吐藥), is a serotonin receptor agonist.

5. Which of the following descriptions about neuronal action potential is incorrect? (A) It requires sodium channel and potassium channel to work together. (B) When sodium channel opens, it depolarizes the neuronal membrane and promotes potassium channel opening. (C) Sodium channel opens faster than potassium channel. (D) Sodium channel requires potassium channel to close.

6. Which of the following descriptions about tricyclic antidepressant (TCA) is incorreet? (A) It inhibits the reuptake of serotonin at the presynaptic site. (B) It inhibits the reuptake of norepinephrine at the presynaptic site. (C) A common side effect of TCA is dry mouth. (D) It suppresses the degradation of monoamine at the presynaptic site.

7. Which of the following descriptions about thyroid related drugs is incorrect? (A) In patients with hypothyroidism, thyroxine (T4) supplement is a therapeutic option. (B) Radioactive iodine () can destroy thyroid gland because it accumulates in the thyroid stromal cell itself. (C) Propylthiouracil (PTU) is a drug for hyperthyroidism that inhibits thyroid hormone synthesis by inhibiting thyroid peroxidase. (D) Thiocyanate is a drug for hyperthyroidism that inhibits sodium-iodine symporter.

8.下列有關抗瘧疾藥的敘述,何者正確?(A)Chloroquine 無法殺死紅血球中的症原蟲。(B)Quinine無法殺死紅血球中的瘧原蟲。(C)Primaquine 無法殺死紅血球中的原蟲(D)以上皆是

9.下列有關寄生蟲藥物的敘述·何者正確?(A)Abendazole 可以殺死所有的寄生蟲。(B)Abendazole的作用機轉是結合beta-tubulin,抑制微小管(microtubule)之聚合作用。(C)Abendazole 必须要和Praziquantel 併用(D)praziquantel的作用機轉是抑制有calcium進入寄生蟲的细胞,造成蟲體癱軟而被排出。

10.下列有關selective serotonin reuptake inhibitor(SSRI)的說明,何者錯誤?(A) SSRI常被作為抗憂鬱藥使用。(B) SSRI 一般在個小時內,就能發揮藥效。(C) SSRI的其中一個副作用,是體內有太多serotonin,產生sotosto(D)SSRI不能和monoamine oxidase inhibitor(MAOI併併用,可能會出現 malignant hypertension.

() 1. Aspirin could be used to stop heparin-induced intestinal bleeding.(A)O(B)X

()2. Ketorolac could be used to treat chronic renal failure.(A)O(B)X

3. Acetaminophen suppresses both cyclooxygenase (COX)-1 and COX-2.(A)O(B)X

4. Isoniazid may cause peripheral neuritis.(A)O(B)X

5. Rifampin, if properly taken, always causes orange-color urine.(A)O(B)X

6. The activation of Pyrazinamide requires the presence of protons.(A)O(B)X

7. The activation of Pantoprazole requires the presence of protons.(A)O(B)X

8. Cimetidine might cause galactorrhea in male patients.(A)O(B)X

()9. Magnesium-containing antacids might cause dianrhea.(A)O(B)X

() 10. Metoclopramide stops diarthea by blocking the serotonin 5-HT₄ receptor.(A)O(B)X

() 11. Octreotide could be used to treat recalcitrant constipation.(A)O(B)X

12. Allopurinol suppresses muscarinic cholinergic receptors to inducc hyperuricemia.(A)O(B)X

() 13. Rapid absorption of Mesalamine in the intestine is mandatory for its effectiveness in the treatment of Crohn's disease.(A)O(B)X

()14. Long-term use of Prednisolone is not suggested for the treatment of ulcerative colitis.(A)O(B)X

()15. Tenofovir could be used to treat the infection of hepatitis B virus (HBV) and human inmunodeficiency vinus (HIV).(A)O(B)X

() 16. Diazepam could be used to stop status epilepticus.(A)O(B)X

()17. Zolpidem blocks the activity of GABAa receptors, so it could be used to relieve the intoxication of benzodiazepines (BZDs).(A)O(B)X

() 18. Suvorexant suppresses melatonin receptors to induce sleep.(A)O(B)X

() 19. It takes three hours for Venlafaxine to effectively relieve anxiety.(A)O(B)X

() 20. Granisetron may causc carsick by activating the dopamine D1 receptor.(A)O(B)X

1. Which antiplatelet drug can induce coronary steal phenomenon and cannot be used in unstabie angina patients? (A) Dipyridamole (B) Aspirin (C) Abciximab (D) Clopidogrel

2. Entresto is used for heart failure treatment. Which is not the action mechanism of entresto? (A) Inhibit neprelysin by sacubitril (B) Inhibit AT1 receptor by valsartan (C) Inhibit neprelysin by LBQ657 (D) Activate AT2 receptor by irbesartan

3. Anticoagulants may prolong the bleeding time, Once the anticoagulant induces bleeding problem, which is the correct match of the anticoagulant and its antidote? (A) Andexxa is the antidote for dabigatran (B) Idarucizumab is the antidote for dabigatran (C) Agartroban is the antidote for heparin (D) Vitamin K3 is the antidote for warfarin

()4. Which antihypertensive drug does not have the side effect of hyperkalemia? (A) Spironolactone (B) Aliskiren (C) Prazosin (D) Triamterene

)5. Paroxysmal supraventricular tachycardia (PSVT) may be caused by abnornal AV nodal conduction. Which drug and its action mechanism can be used for PSVT treatment? (A) Ranolazinc, slow activating calcium channel blocker (B) Adenosine, Al receptor activator (C) Pindolol, B adrenoceptor blocker (D) Quinidine, M receptor activator

()6. Which is the action mechanism and side cffect of Ivabradine? (A) Ic inhibitor, constipation (B) INa inhibitor, thrombocytopenia (C) Iinhibitor, luminous phenomena (D) IKs inhibitor, long QT

()7. Which is the action mechanism of central acting antihypertensive drugs? (A) Activate presynaptic a l adrenoceptor (B) Activate presynaptic a2 adrenoceptor (C) Inhibit postsynaptic B adrenoceptor (D) Inhibit postsynaptic M1 receptor

8. Which antiarhythmic drug can increase the effective refractory period of cardiac action potential but does not prolong action potential duration? (A) Quinidine (B) Procainamide (C) Mexiletine (D) Sotalol

9. Which is NOT the hemodynamic benefit of AT1 blocker or angiotensin-converting enzyme inhibitor (ACEI) for long term use in post myocardial infarction patients? (A) Reduce water retention (B) Reduce afterload (C) Reduce cardiac remodeling (D) Reduce ventricular cjection time

10. Which drug can reduce cardiac oxygen consumption through decreasing ventricular ejection time to improve angina symptoms? (A) Nitroglycerin (B) Pindolol (C) Hydralazine (D) Bisoprolol

()1下列有關Fluoxetne的敘述何者錯誤?(A)可以用於治療bipolar depression 皮暴食症(B)對codeine的止痛效果有增加效果(C)會有焦慮及失眠的副作用(D)對CYP2D6有强效的抑制作用

2下列藥物何者常使用於肠道假阻塞(colonicpseudo-obstruction)的住院病人? (A) Alvimopan (B) Lubiprostone (C) Magnesium hydroxide (D) Neostigmine

3.下列藥物何者可用於便秘型的大腸激躁症(constipation-predominant imitablebowesydrome)? (A) Alosetron (B) Linaclotide (C) Metoclopramide (D) Infiximabb

4.下列是治療psoriasis的藥物,其有關的作用敘述何者錯誤?(A)Secukinumab是IL-17A的抗體,感染是其主要的副作用(B)Acitretin 與酒精反應產生etretinate而加逸排泄(C)Calcipotriene與betamethasone 合用可以增加療效(D)Apremilast是PDE4抑制劑,會增加憂鬱症的機率

5.下列有關Ciprofloxacin的敘述何者正確?(A)主要作用機制是抑制細菌的dihydrofoliccidreductase(B)與Azithromycin 合用是治療淋球菌(gonococcus)的首選築物(C)與其他quinolone 類藥物不同,無法抑制CYP3A4(D)治療葡萄球菌(Sstaphylococci)感染時可以與Rifampin合用

6.下列有關制酸劑的敘述何者錯誤? (A)使用NaHCO₃於肾臟功能不佳的病人,容易導致metabolicalkalosis (B)使用高量NaHCOg₃且食用高鈣食物時，容易導致高钙血症(hypercalcemia) (C) AI(OH)₃較CaCO₃容易產生便秘 (D)一般同時服用Mg(OH)₂及Al(H)的目的主要是避免打嗝

7.下列有關Allopurinol的敘述何者正確?(A)會促進Azathioprine的毒性(B)最初開始使用Allopurinol時,必須停用Colchicine(C)Allopurinol會促進口服抗凝劑的代謝(D)Ilopurinol對特發性高钙尿症(idiopathic hypercalciuri)無治療效果

8.下列降血糖藥物何者是經由抑制DPP.4? (A) Canaglifozin (B) Linagliptin (C) Liraglutide (D)Tolbutamide

()9.下列藥物何者無法用於Osteoporosis治療? (A) Calcitonin (B) Cinacalcet (C) Denosumab (D) Teriparatide

()10.下列藥物何者無法用於idiopathic thrombocytopenic pupura治療? (A) Adalimumnab (B) Cyclophosphamide (C) Gammaglobulin (D) Vincristine

申論題 (4)

1 報載金正男是被用神经毒氣VX毒殺,試以藥理作用闡述為何VX性這麼強,可以在口鼻接觸後幾分鐘內斃命,如果來得及可以有解藥嗎?(5%)

2.試述全身麻醉藥引起惡性高熱的可能原因及處理之道。(4%)

3.試以藥理的觀點解釋大麻、古柯、和海洛英成瘾的原因和需要列管的理由。(6%)

4.報載我有一車祸意外的肇事男子(70kg)酒測值高達0.56,推估當時他的血中乙醇濃度為何?若他酒後再等多少小時才開卓上路,悲劇可能就能避免?(alcohol metabolic rate:100 mg/kg/hr)(5%)

110年 - 110 國立臺灣大學_碩士班招生考試_部分系所:藥理學#102017

試卷資訊

選擇題 (50)

申論題 (4)