複選題33. Gene activities in the nucleus could be regulated by signaling that is initiated at the plasma membrane. Which of the following descriptions are correct? (A) The general principle of such signaling involves nuclear translocation of a transcriptional regulator protein upon activation of the signaling event (B) Wnt-Frizzled signaling activates glycogen synthase kinase 3ẞ (GSK3B), which promotes ẞ-catenin nuclear translocation by phosphorylation (C) Mitogen-activated protein kinase (MAPK) signaling in yeast often requires scaffold proteins to facilitate serial activation of MAPKKK, ΜΑPKK and MAPK (D) Nuclear Factor кВ (NF-kB) is a common mediator of G protein-coupled receptor signaling (E) Nuclear translocation of Smad proteins mediate the effects of transforming growth factor ẞ (TGF-β) signaling