1.下列何種治療不適用於隱球菌（Cryptococcus neoformans）引起的腦膜炎？
(A)併用amphotericin B 0.5 mg/kg/day IV及flucytosine 100 mg/kg/day
(B)Liposomal amphotericin B 4 mg/kg/day IV
(C)Micafungin 150 mg qd IV
(D)併用fluconazole 400 mg/day及amphotericin B 0.7 mg/kg/day

＊快速抗黴菌藥整理
-Azole: 

打腦打尿：fluconazole [cryptococcus, candida]
打腦不打尿：voriconazole [candida, aspergillus] 口服吸收好
不打腦尿：intraconazole [最常for dermatophytoes & onychomycosis x12week] 
幾乎什麼黴菌都可打:posaconazole ，台灣只有口服（配高脂吃

-echinocandin [candida, aspergillus]: mica/amidula/capso -fungin
不打腦尿、貴、安全、neutropenic fever fungal infection 經驗性用藥

-其他
IV: Amphotericin, flucytosine
topical: Nystatin

Caspofungin沒辦法進入CSF

心想事成 Fluconazole is an alternative to AmB in patients infected with HIV with cryptococcal meningitis. It is important to be mindful of the following caveats, however: Sterilization of the CSF occurs more rapidly and mortality is lower during the first 2 weeks of therapy in patients treated with AmB as compared with fluconazole.176,194 Early mortality was especially high in fluconazole-treated patients who presented with altered mental status. Thus, initial therapy of cryptococcal meningitis in patients with mental status changes should be initiated with AmB for at least 2 weeks or until the patient has stabilized clinically. At this point, fluconazole may be substituted at an initial dosage of 400 mg/day for up to 10 weeks.

Applied Therapeutics 有這一段, 感覺好像可以一起短暫使用, 再換成Fluconazole

請問一下D選項，因為它們機轉的關係，azole類的不是不能跟Amphotericin B 併用嗎？