試題詳解

10. A 56-year-old man with cryptococcal meningitis is being treated with flucytosine and amphotericin B. Flucytosine is metabolized to 5-flurouracil by fungal cells which inhibits DNA synthesis. The selectivity of flucytosine is due to a lack of which enzyme in mammalian cells？
(A)Cytosine deaminase
(B)N-acetyltransferase
(C)Uracil phosphoribosyl transferase
(D)Thymidylate synthetase