13.Regarding topoisomerase, which of the following statements is/are CORRECT? (A) Type I topoisomerase cleaves only one strand of DNA (B)Type II topoisomerase causes double-strand breaks and requires ATP (C)One of the functions of topoisomerase is to relieve the supercoiling tension (torsional stress) caused by replication or transcription (D)DNA gyrase can introduce negative supercoils in bacteria (E)Topoisomerase only functions during transcription and is unrelated to replication