試題詳解

19. As topoiosomerases play an important role during replication, a large number of anticancer drugs have been developed that inhibit the activity of these enzymes. Which of the following statements is NOT true about topoisomerases as a potential anticancer drug target?
(A) As cancer cells are rapidly growing cells, they usually contain higher level of topoisomerases.
(B) The transient DNA breaks created by topoisomerases are usually converted to permanent breaks in the genome in the presence of topoisomerase targeted drugs.
(C) As cancer cells often have impaired DNA repair pathways, they are more susceptible towards topoisomerase targeted drugs.
(D) The drugs that specifically target topoisomerase, usually do not affect normal fast growing cells.