試題詳解

22. In TGF-b pathway, R-Smads are activated by phosphorylation and form complex with Smad4, then this complex enter nucleus. Which of the following statement is   not   correct?
(A) If the oligomerization domain on R-Smads is deleted, the TGF-b signaling is more active.
(B) If the NLS (nuclear localization signal) on Smads is lost, TGF-b signaling will be reduced.
(C) ubiquitination for protein degradation on R-Smads will promote signaling
(D) over-expression phosphatase for R-Smads will reduce signaling