25. What is the main difference between mismatch repair (MMR) in eukaryotes and prokaryotes? (A) Eukaryotes lack a functional Mut H and Dam methylase. (B) Eukaryotes have proteins homologous to MutS and MutH but not MutL. (C) Eukaryotes only repair the lagging strand. (D) Prokaryotic MMR can repair small loops of unpaired nucleotides, whereas eukaryotes cannot. (E) Both use exonucleases to eliminate the mismatched strand but eukaryotes only require 3'-5' exonucleases.

3. Consider an experiment in which nucleic acids are separated using agarose gel electrophoresis. In the gel you load the following samples: Lane 1: a population of linearized 3000-bp double-stranded DNA (dsDNA) molecules. Lane 2: a population of circular 3000-bp double-stranded DNA (dsDNA) molecules Which population of nucleic acids would most likely migrate through the gel fastest, and in which direction through the gel will these molecules migrate? (A) The linearized dsDNA would most likely migrate faster than the circular dsDNA. AlI DNA molecules would migrate toward the positive end of the gel. (B) The linearized dsDNA would most likely migrate faster than the circular dsDNA. AIl DNA molecules would migrate towards the negative end of the gel. (C) The circular dsDNA would most likely migrate faster than the linearized dsDNA. All DNA molecules would migrate toward the positive end of the gel. (D) The circular dsDNA would most likely migrate faster than the linearized dsDNA. All DNA molecules would migrate toward the negative end of the gel

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