39.承上題,下列那一種抗癲癇藥物常用來治療此病童之癲癇發作?
(A)Valproic acid
(B)Lithium carbonate
(C)Phenytoin
(D)Diazepam
統計: A(3320), B(125), C(459), D(301), E(0) #415081
詳解 (共 10 筆)
【Seizure】
1. 局部性
(1) 單純性: Phenytoin(㊀Na+-channel)、Carbamazepine(㊀Na+-channel)、Valproic acid(㊀Na+, Ca+-channel; transaminase inhibitor→GABA↑)
(2) 複雜性: (同上)
2. 全身性
(1) 大發作: (同上)
(2) 小發作: Ethosuximide(㊀Ca+-channel)、Valproic acid
(3) 失神性: Ethosuximide(㊀Ca+-channel)、Valproic acid
(4) 重積性: Diazepam、Lorazepam
(5) 肌痙性: Valproic acid
(6) 兒童熱痙攣: Phenobarbital
(B) Lamotrigine
(C) Phenytoin
(D) Valproic acid
valproic acid 可以用在局部性、大發作、小發作(失神性)、肌肉痙攣性發作 (除了重症積、小兒熱痙攣之外都可以)
萬一真的忘了 就選爆valproic acid吧
Author:Angus Wilfong, MDSection Editor:Douglas R Nordli, Jr, MDDeputy Editor:John F Dashe, MD, PhD
Immediate pharmacologic therapy — SE should be treated immediately, as treatment delay is associated with increased morbidity and mortality [23-25].
●First therapy: Benzodiazepine – Lorazepam 0.1 mg/kg intravenously (IV) up to a maximum of 4 mg should be administered by slow IV push over one minute and its effect assessed over the next five to ten minutes [26]. An equally effective alternative is diazepam 0.2 mg/kg IV (maximum dose 8 mg) [26,27]. If seizures continue after five minutes, additional doses of lorazepam or diazepam can be given (table 2). The risk of respiratory depression increases if more than two doses of benzodiazepines are administered [7,9]. (See 'Benzodiazepines' below.)
Benzodiazepines — Benzodiazepines are the first-line treatment for SE because they can rapidly control seizures [13,21]. The three most commonly used benzodiazepines to treat SE are diazepam, lorazepam, and midazolam; for first-line IV therapy, lorazepam or diazepam are the preferred agents.
想請問一下,在兒童熱痙攣用藥方面是否有誤?
另外,摘錄自快樂小藥師: