42. Which one of the following statement is wrong? (A) The person who has a chronic pain condition resides in a complex and costly world that is populated not only by themselves but also by their significant others, including health care providers, employers, and third-party payers. (B) People with chronic pain may feel that their health care providers, employers, and even family members are blaming them when their condition fails to respond to treatment as expected. (C) In the absence of cure or even substantial relief, individuals experiencing chronic pain may withdraw from contacts； lose their sources of income； alienate family, friends, and coworkers； and become more and more isolated, despondent, depressed, and, in general, demoralized. (D) Psychosocial and behavioral factors play an insignificant role in the experience, maintenance, and exacerbation of pain and potentially even the cause. (E) Because some level of pain persists in the majority of people with chronic pain regardless of treatment, self-management is an important complement to biomedical approaches.