46 王小弟今年 10 歲患有失神性發作（absence seizure），下列處置何者最為適當？
(A)因 valproate 較不易造成嗜睡的副作用，建議先以每日口服 5-10 mg/kg 治療
(B)因 zonisamide 不需進行血中濃度監測，建議先以每日口服 100 mg 治療
(C)因 gabapentin 較不易與其他藥品產生交互作用，建議先以每日口服 100 mg 治療
(D)因 topiramate 副作用少，建議先以每日睡前口服 50 mg 治療

zonisamide 

Partial Seizures Initial: 100 mg PO qDay
Titrate up by 100 mg increments q2Week to no more than 600 mg PO qDay (may divide q12hr after 1st week)

topiramate

Partial-Onset or Primary Generalized Tonic-Clonic Seizures

Monotherapy

Topamax, Topamax Sprinkles: 25 mg PO q12hr initially; may increase by 50 mg/day at weekly intervals to 200 mg PO q12hr

Trokendi XR, Qudexy XR: 50 mg PO qDay initially; may increase by 50 mg/day at weekly intervals for first 4 weeks, then 100 mg/day for weeks 5 to 6; target dose is 200-400 mg/day for partial onset seizures and 400 mg/day for generalized seizures

Adjunctive therapy

Topamax, Topamax Sprinkles: 25-50 mg/day PO initially; increase by 25-50 mg/day at weekly intervals to 100-200 mg q12hr for partial onset seizures and 200 mg q12hr

Trokendi XR, Qudexy XR: 25-50 mg PO qDay initially; increase by 25-50 mg/day at weekly intervals to achieve effective dose; not to exceed 200-400 mg/day

[引用] diltiazem.a 國三下 (2014/03/11) 

治療失神性發作:ehosuximide,valproate,clonazepaam