50. In excess, cortisol has aldosterone-like effects in the kidney causing salt and water retention. This is because the capacity of 11-hydroxysteroid dehydrogenase type 1 enzyme that converts active cortisol to inactive cortisone in the kidney tubule is destroyed. This may be a factor in the hypertension seen in patients with Cushing's syndrome. What is the mechanism regarding this outcome? (A) Cortisol is then available to interact with the cortisol receptor, which exist in the kidney. (B) Cortisol is then available to interact with the aldosterone receptor for which it has equal affinity. (C) Cortisol is then available to interact with the androgen receptor for which it has equal affinity. (D) Cortisol is then available to interact with the progestin receptor，which exist in the kidney. (E) none of them.