試題詳解

6. Which one of the following statements is wrong?
(A) Neuron–glial interactions are increasingly recognized as being key for physiological and pathological processes in the central nervous system.
(B) Microglia in the spinal dorsal horn respond to injury to peripheral nerves by adopting a specific response state characterized by up-regulation of the purinergic receptor P2X4.
(C) In this P2X4R+ state, microglia release brain-derived neurotrophic factor, which disinhibits neurons in the spinal nociceptive processing network.
(D) The transformation in processing caused by signaling of P2X4R+ microglia to nociceptive transmission neurons may account for the main symptoms of neuropathic pain in humans.
(E) All of the above are correct.