65 下列藥品中，何者較不會引起血中尿酸值升高的不良反應？
(A) Cyclophosphamide
(B) Furosemide
(C) Indomethacin
(D) Pyrazinamide

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統計： A(99), B(139), C(169), D(30), E(0) #413084

詳解 (共 3 筆)

#790553
Indomethacin 可用於急性痛風
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#1207312
ㅤㅤ 1. Cyclophosph...
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Pyrazinamide is a strong urate retention agent, causing a greater than 80% reduction in renal clearance of uric acid at a 300-mg therapeutic daily dose. The metabolite pyrazinoic acid is oxidized by xanthine oxidase and is likely responsible for the hyperuricemic effect.

Pyrazinamide與uric acid競爭xanthine oxidase，所以造成hyperuricemic effect.
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Ethambutol can also cause hyperuricemia by decreasing renal uric acid clearance, but it does so less consistently and to a lesser degree than pyrazinamide.
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Ethambutol會降低uric acid的腎清除，但其影響程度小於pyrazinamide.
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Pham AQ, Doan A, Andersen M. Pyrazinamide-induced hyperuricemia. P T. 2014 Oct;39(10):695-715. PMID: 25336865; PMCID: PMC4189695.
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私人筆記 (共 1 筆)

私人筆記#5320078
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REF：台灣痛風與高尿酸血症診療指引引起...
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